Medicine Bottle Series Blow Molding Machines

Automatic PET blow molding machines for pharmaceutical medicine bottles. 9 models, 2–6 cavities, 7–98 mm neck, 1,800–7,200 bph. GMP no-hand-contact. Incl. eye-drop 7 mm narrow-neck platform. CE.

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PET Blow Molding Expert · Medicine Bottle Series Guide

Medicine Bottle Series
Blow Molding Machines — Complete Model Guide

9 models across AS and ES series — two-step automatic PET and PETG stretch blow molding machines purpose-built for pharmaceutical, medical, and healthcare bottle production. Featuring the first domestically developed 7 mm ultra-narrow-neck automatic machine for eye-drop and precision-dosage containers, no-hand-contact production for GMP compliance, and AS-grade high-precision servo drive for complex pharmaceutical bottle geometries. A performance-matched, cost-effective alternative to Sidel, Krones, SMI, and Sipa platforms.
► 2 – 6 Cavities
► 500 ml – 1,500 ml
► 1,800 – 7,200 bph
► Neck from 7 mm – 98 mm
► GMP No-Hand-Contact
► CE Certified

medicine bottle series PET blow molding machine pharmaceutical eye drop oral liquid tablet bottle GMP production

1. Product Overview

The Medicine Bottle Series Blow Molding Machines comprise 9 models across the AS and ES sub-series, engineered specifically for the stringent dimensional accuracy, surface quality, and no-hand-contact production requirements of pharmaceutical, medical, and healthcare bottle manufacturing. The series spans from the AS-grade high-precision servo platform for complex pharmaceutical bottle geometries, through standard servo ES-series models for oral liquid, tablet, and supplement containers, to the pioneering ES-3C76 narrow-neck platform — the first domestically developed automatic machine capable of producing containers with neck diameters as small as 18 mm, enabling fully automated production of eye-drop bottles, nasal-spray containers, and precision-dosage pharmaceutical vials.

All models in this series produce PET and PETG containers with no-hand-contact operation throughout the preform feed, oven conditioning, and blow cycle — satisfying the fundamental GMP requirement that primary packaging material has no direct human contact during production. PET and PETG offer compelling advantages over glass in pharmaceutical packaging: equivalent chemical inertness for aqueous formulations, superior drop resistance eliminating the breakage risk that contaminates filling lines, and crystal clarity that enables visual product inspection, fill-level verification, and colour-coded identification without label removal.

The AS-series models deliver the additional per-cavity servo precision required for pharmaceutical bottles with non-circular cross-sections, asymmetric shoulder profiles, or fine-detail neck-finish geometries that must meet tighter closure engagement tolerances than standard beverage or cosmetic applications.

Applicable Industries & Applications

✓ Eye-Drop Bottles (7–18 mm neck)
✓ Nasal Spray & Ear-Drop Containers
✓ Oral Liquid & Syrup Bottles
✓ Tablet & Capsule Containers
✓ Nutraceutical & Supplement Bottles
✓ Diagnostic Reagent Containers
✓ Hotel Amenities & Travel Toiletries
✓ Veterinary & Animal Health Packaging

2. Working Principle

All models operate on the two-step reheat stretch blow molding (RSBM) process. Pharmaceutical-grade PET or PETG preforms are automatically fed from a gravity hopper, sorted neck-up by an orientation bowl, and conveyed through a multi-zone NIR oven on pitched mandrel holders — at no stage does operator hands contact the preform or the interior of the blown bottle.

At the blow station, servo stretch rods extend axially within each cavity while low-pressure air initiates radial expansion, followed by a high-pressure blast (26–35 kg/cm²) that drives PET or PETG against the cooled mold wall. Biaxial molecular orientation achieved during this simultaneous axial-radial stretching dramatically increases tensile strength, chemical barrier performance, and drop resistance of the finished pharmaceutical container.

The ES-3C76 narrow-neck platform requires a specialised preform handling and mandrel system designed for neck diameters as small as 18 mm — dimensions that standard pharmaceutical blow molder handling systems cannot accommodate. The oven mandrel pitch (76 mm) and transfer mechanism are precision-engineered to hold, orient, and transfer ultra-narrow-neck preforms without distortion or contamination of the inner surface.

Key structural components: servo-electric toggle-link clamping • per-cavity servo stretch rod • multi-zone NIR oven with pharmaceutical-grade neck-protection cooling collar • no-hand-contact automatic preform feeder and orientation system • Siemens/Mitsubishi PLC with HMI, recipe storage, and production batch logging • inline dimensional and weight rejection system.

3. Core Advantages

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7 mm Ultra-Narrow Neck — Industry First

The ES-3C76 is the first domestically developed fully automatic stretch blow molder capable of producing containers with neck diameters down to 18 mm (with 7 mm capability available) — enabling automated production of eye-drop bottles, nasal-spray vials, and precision-dosage pharmaceutical containers that previously required manual or semi-automatic processes.

No-Hand-Contact — GMP Compatible

Fully automated preform feed, oven conveying, blow cycle, and bottle discharge means no operator hand contact with preforms or bottle interiors at any production stage — satisfying the fundamental GMP requirement for primary pharmaceutical packaging material and supporting HACCP and BRC compliance submissions at filling facilities.

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AS-Grade Servo Precision

AS-series models use higher-specification servo motors and precision reducers delivering ±0.03 mm stretch-rod positioning accuracy — exceeding standard ES-series performance for pharmaceutical bottles with complex asymmetric geometries, fine-pitch neck finishes for child-resistant closures, or premium bottle profiles requiring tighter dimensional tolerances than standard packaging applications.

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1,800 to 7,200 bph — Full Range

From 2-cavity 1,800 bph platforms for specialised pharmaceutical brands through to 6-cavity 7,200 bph lines for mass-market nutraceutical and supplement production — the series covers the full throughput range of pharmaceutical and healthcare bottle manufacturing without the need for multiple machine types.

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PET & PETG — Pharmaceutical Grade

Both PET and PETG are globally approved for direct pharmaceutical contact. PETG offers superior clarity and glossiness for premium oral-care and supplement presentations. Both materials are processed without hardware modifications — oven zone profiles and PLC recipes for each material are stored on-board, enabling rapid changeover between resins for different product categories.

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Complete Turnkey Supply

We supply blow molds (including precision pharmaceutical neck-finish tooling), preform injection molds, industrial chillers, and oil-free compressor packages from a single source — ensuring ISO 8573-1 Class 1 oil-free air quality compliance mandatory for direct-contact pharmaceutical packaging, and simplifying procurement for regulated pharmaceutical manufacturing environments.

PET pharmaceutical medicine bottles eye drop oral liquid tablet supplement containers produced by medicine bottle blow molding machines

4. Technical Specifications

▶ AS Series — High-Precision Pharmaceutical Specialist (2 & 4 Cavity, PET / PETG)

2 models. Higher-grade AS servo motors and precision reducers for complex pharmaceutical bottle geometries, asymmetric profiles, and fine-pitch child-resistant neck finishes. Exceeds standard ES-series dimensional tolerance for regulated pharmaceutical packaging.

Parameter / Unit AS-2C114.3 AS-4C76.2
Cavities 2 4
Max. Container Volume (ml) 1,000 500
Output (bph) 2,000 4,000
Max. Neck Diameter (mm) 88 48
Max. Body Diameter (mm) 94 65
Max. Container Height (mm) 260 250
Clamping Stroke (mm) 122 100
Stretching Stroke (mm) 400 350
Preform Holder 48 96
Max. Heating Power (kW) 45 33
Normal Heating Power (kW) 20 17
Blowing Pressure (kg/cm²) 35 35
HP Air Consumption (L/min) 1,600 4,000
Cooling Water Flow (L/min) 30 40
Machine Size L×W×H (mm) 2660×1660×2150 3370×1850×2100
Machine Weight (kg) 2,600 4,000

▶ ES Series — Standard Servo Pharmaceutical & Healthcare Bottles (2 / 3 / 4 / 6 Cavity, PET / PETG)

7 models covering 500 ml to 1,500 ml. Includes the ES-3C76 narrow-neck specialist (18–38 mm neck) for eye-drop and precision-dosage containers, and the ES-6C76 high-speed platform at 7,200 bph for nutraceutical and supplement mass production.

Parameter / Unit ES-2C100 ES-2C114.3 ES-2C130 ES-3C76 ★ ES-4C76 ES-4C100 ES-6C76
Cavities 2 2 2 3 4 4 6
Max. Volume (ml) 500 1,000 1,500 700 700 800 700
Output (bph) 2,400 2,000 1,800 3,000 4,800 4,600 7,200
Max. Neck Dia. (mm) 68 88 98 18–38 ★ 48 68 68
Max. Body Dia. (mm) 80 94 110 68 68 80 68
Max. Height (mm) 200 260 250 240 240 250 240
Clamping Stroke (mm) 110 132 160 100 100 128 100
Stretching Stroke (mm) 350 400 350 240 350 350 350
Preform Holder 60 60 60 72 96 92 130
Max. Heating Power (kW) 34 50 42.5 40 40 62.5 62.5
Normal Heating Power (kW) 8–12 16 8–13 18 18 21 26
Blowing Pressure (kg/cm²) 26–35 35 26–35 35 35 35 35
HP Air (L/min) 1,000–1,400 1,000 1,000–1,500 2,400 3,900 4,000 5,800
Cooling Water Flow (L/min) 30 30 30 30 30 30 40
Machine Size L×W×H (mm) 2900×1525×1930 3220×1660×2010 3600×1800×1980 2850×1850×2180 3290×1850×2260 4170×1930×2340 4690×2000×2000
Machine Weight (kg) 2,000 3,000 3,000 3,500 3,500 4,000 5,500
★ ES-3C76 Note: Neck diameter range 18–38 mm covers the ultra-narrow-neck segment including 7 mm capability for eye-drop bottle production — the first domestically developed fully automatic machine for this format. Specialised narrow-neck preform mandrel and transfer system fitted as standard.

⚡ Compressed Air — Pharmaceutical-Grade Requirement: All models require low-pressure air at 7 kg/cm² and high-pressure air at 26–35 kg/cm². For direct-contact pharmaceutical packaging, ISO 8573-1 Class 1 oil-free air is mandatory at the blowing point under GMP and virtually all national pharmaceutical packaging regulations. Read our technical guide: why PET stretch blow molding demands 40-bar oil-free compressors — we supply matched pharmaceutical-grade oil-free compressor packages as part of our turnkey solution.

5. Structure & Material Engineering

🛠 Machine Frame & Clamping

Heavy-gauge welded steel frame, stress-relieved and CNC-machined at all guide-rail and bearing surfaces. Toggle-link servo-electric clamping with no hydraulic fluid — eliminating contamination risk in pharmaceutical production environments and extending maintenance intervals. The AS-series clamping mechanism incorporates higher-specification bearings and guide rails than the ES series, supporting the tighter dimensional tolerances required for pharmaceutical neck-finish production.

⚙ Narrow-Neck Mandrel System (ES-3C76)

The ES-3C76 features a precision narrow-neck mandrel and preform transfer system designed specifically for neck diameters of 18–38 mm. Standard pharmaceutical blow molder handling systems cannot accommodate necks below 28 mm without preform jamming or misorientation. The ES-3C76 mandrel geometry prevents these failures at production speeds up to 3,000 bph.

🌡 Pharmaceutical-Grade NIR Oven

Multi-zone NIR quartz-lamp oven with independently controlled zones and a pharmaceutical-grade neck-protection cooling collar. Pharmaceutical preforms span a wide wall-weight range — from ultra-light 1 g eye-drop vial preforms to heavier 50 g oral liquid bottle preforms — requiring individual zone configuration for each application. All oven enclosures are smooth-surface and cleanable, compatible with pharmaceutical facility cleaning protocols.

🔓 Pharmaceutical Mold Materials

Blow mold cavities machined from high-strength aluminium alloy with 3D CAD conformal cooling channels. Pharmaceutical bottle molds incorporate precision child-resistant neck-finish tooling (28 mm CRC, 38 mm CRC, and custom formats) machined to ±0.01 mm on the neck-finish geometry — tighter than standard packaging applications. Preform injection molds use imported 2316 mold steel with 420 stainless cavity plates, CNC-machined to ±0.02 mm.

📱 PLC, Batch Logging & Traceability

Siemens or Mitsubishi PLC with colour HMI touchscreen. Up to 50 bottle-format recipes on-board. The pharmaceutical-grade configuration includes production batch logging — recording output count, cycle time, and oven zone data per batch — supporting the production traceability documentation required by pharmaceutical filling facility quality systems (GMP, ISO 13485).

📈 Inline Rejection System

All non-conforming containers are automatically rejected before the downstream conveyor. In pharmaceutical filling lines where off-specification bottles cause closure failures, fill-level inaccuracy, or leakage, the inline rejection system provides the pre-filling quality gate required by GMP-compliant primary packaging operations.

6. Typical Application Scenarios

🔬 Eye-Drop & Nasal-Spray Containers

The ES-3C76 is the primary platform for eye-drop bottle (7–18 mm neck) and nasal-spray container production. These formats require the ultra-narrow-neck preform handling, precision biaxial orientation for wall thickness uniformity below 0.3 mm, and no-hand-contact production that makes this machine unique in the domestic market. 3,000 bph throughput suits mid-to-high volume ophthalmic pharmaceutical producers.

💊 Oral Liquid & Syrup Bottles

100–500 ml PET oral liquid bottles for cough syrups, antacids, vitamin supplements, and paediatric medications. The ES-2C100 (2,400 bph) and AS-2C114.3 (2,000 bph) cover this segment with neck diameters of 68–88 mm accommodating both child-resistant and standard pharmaceutical screw caps. PETG option delivers premium clarity for high-value formulations.

💉 Tablet & Capsule Containers

200–1,000 ml PET tablet and capsule bottles for prescription and OTC pharmaceuticals. Child-resistant closure (CRC) compatibility is standard — the AS-2C114.3 and ES-2C114.3 produce the 88 mm neck finishes with ±0.1 mm diameter tolerance required for consistent CRC engagement torque values across all bottles in a production batch.

🌿 Nutraceutical & Supplement Bottles

The high-speed ES-4C76 (4,800 bph), ES-4C100 (4,600 bph), and ES-6C76 (7,200 bph) are optimised for mass-market nutraceutical and dietary supplement bottle production — vitamin, mineral, protein, and botanical supplement containers where high throughput and consistent neck-finish quality for induction-seal application are the primary production requirements.

🏠 Hotel Amenities & Travel Toiletries

The ES-3C76 narrow-neck platform (18–38 mm) also produces hotel amenity miniature bottles — 20–100 ml narrow-neck containers for shampoo, conditioner, body wash, and lotion used in hotel, airline, and travel retail packaging. These formats require the same narrow-neck precision as pharmaceutical containers, making the ES-3C76 uniquely capable across both pharmaceutical and premium hospitality packaging sectors.

🐋 Veterinary & Animal Health Packaging

Veterinary pharmaceutical bottles for oral liquids, pour-on treatments, and injection packaging follow GMP-adjacent regulatory requirements similar to human pharmaceutical containers. PET and PETG clarity enables direct verification of product colour and fill level — important for veterinary dosing accuracy. The AS-4C76.2 (4,000 bph, 48 mm neck) suits high-volume veterinary oral liquid and injection bottle formats.

7. Our Machines vs. European Brand Platforms — Objective Comparison

Disclaimer: The brand names Sidel, Krones, SMI, and Sipa are referenced solely to assist buyers in comparing technical specifications and making informed sourcing decisions. We are an independent manufacturer with no affiliation with or endorsement from any of these brands. We do not manufacture or sell their products. This comparison does not constitute intellectual property infringement of any kind.
Comparison Item Sidel SBO Series Krones Contiform SMI Smiflexi Sipa SFR EVO Our Series
Origin France Germany Italy Italy Asia
Min. Neck Diameter ~18 mm (selected) ~18 mm (selected) ~20 mm ~18 mm (selected) 7 mm (ES-3C76)
GMP No-Hand-Contact Yes Yes Yes Yes Yes — all models
Approx. Entry CapEx (2-cav.) USD 180K – 280K USD 160K – 260K USD 120K – 200K USD 130K – 210K Significantly lower — direct
AS-Grade Precision Option Selected models Selected models Standard only Standard only AS series — 2 dedicated models
Spare Parts Lead Time 4–12 weeks 4–10 weeks 4–10 weeks 4–10 weeks 3–7 days (stocked)
After-Sales Service Regional agents Regional agents Regional agents Regional agents Direct + remote video
CE Certification Yes Yes Yes Yes Yes

CapEx figures are indicative market estimates. Our pricing is provided by confirmed quotation only.

8. Model Selection Guide

Your Requirement Recommended Model
Eye-drop / nasal-spray vials, 7–18 mm neck, 3-cavity ES-3C76 (3 cavity, 3,000 bph)
Oral liquid / syrup, 100–500 ml, 68 mm neck, mid-volume ES-2C100 (2 cavity, 2,400 bph)
Complex pharmaceutical bottle, asymmetric / CRC neck, precision AS-2C114.3 (AS-grade, 2,000 bph)
Tablet / capsule container, 200–1,000 ml, 88 mm neck AS-2C114.3 or ES-2C114.3 (2,000 bph)
High-speed tablet / supplement bottle, 48 mm neck, 4-cavity AS-4C76.2 (4,000 bph) or ES-4C76 (4,800 bph)
Nutraceutical / supplement, 800 ml, 68 mm neck, high-volume ES-4C100 (4,600 bph)
Oral liquid, up to 1,500 ml, 98 mm neck ES-2C130 (1,800 bph)
Mass-market supplement / nutraceutical, 9,200 bph scale ES-6C76 (6 cavity, 7,200 bph)

pharmaceutical medicine bottle samples oral liquid tablet supplement eye drop PET PETG containers

9. Frequently Asked Questions

Q1: Does no-hand-contact production satisfy GMP requirements for pharmaceutical packaging?
Yes. The fundamental GMP requirement for primary pharmaceutical packaging is that no operator hand contacts the packaging material interior during production. All models in this series achieve this through fully automated preform feed, oven conveying, blow cycle, and bottle discharge — with no manual handling at any stage. We can provide machine architecture documentation confirming no-hand-contact production for inclusion in pharmaceutical Quality Management System submissions (GMP, ISO 13485, BRC).
Q2: What makes the ES-3C76 unique for eye-drop bottle production?
Eye-drop bottles require neck diameters of 7–18 mm — significantly narrower than the 28 mm minimum neck that standard pharmaceutical blow molder handling systems can process. The ES-3C76 features a precision narrow-neck mandrel and transfer system purpose-built for 18–38 mm neck diameters (with 7 mm capability available), enabling fully automatic production of eye-drop and nasal-spray containers at 3,000 bph — replacing semi-automatic or manual production methods that introduce contamination risk and output variability.
Q3: What is the difference between AS-series and ES-series models for pharmaceutical applications?
AS-series models use higher-specification servo motors and precision reducers delivering ±0.03 mm stretch-rod positioning accuracy versus ±0.05 mm for standard ES-series models. This additional precision is required for pharmaceutical bottles with complex asymmetric geometries, fine-pitch child-resistant closure neck finishes requiring tighter engagement torque tolerances, or premium bottle profiles where dimensional deviation would cause visual or functional quality failures in downstream filling and closure application. For standard oral liquid and tablet bottles without special geometry requirements, ES-series models are fully adequate for pharmaceutical production.
Q4: Are PET and PETG materials approved for pharmaceutical packaging?
Yes. Both PET (Polyethylene Terephthalate) and PETG (Glycol-modified PET) are globally approved for direct pharmaceutical contact under USP Class VI, FDA 21 CFR, EU Regulation 10/2011, and equivalent national pharmacopoeia standards for aqueous formulations. PETG offers superior clarity and surface gloss for premium pharmaceutical presentations. Neither material requires food-contact or pharmaceutical-contact certification of the machine itself — the material certification applies to the resin grade used for preform production.
Q5: What compressed air specification is required for pharmaceutical bottle production?
All models require low-pressure air at 7 kg/cm² and high-pressure air at 26–35 kg/cm². For pharmaceutical bottle production, ISO 8573-1 Class 1 oil-free air is mandatory at the high-pressure blowing point — hydrocarbon oil mist from a non-oil-free compressor would contaminate the bottle interior and constitute a GMP failure. We supply matched pharmaceutical-grade oil-free high-pressure compressor packages as part of our turnkey solution.
Q6: Can the machines produce child-resistant closure (CRC) compatible bottles?
Yes. Child-resistant closure compatibility requires the bottle neck-finish to be machined to ±0.1 mm diameter tolerance for consistent CRC engagement torque. AS-series models achieve ±0.05 mm neck-finish tolerance — exceeding the CRC requirement. ES-series models achieve ±0.2 mm — adequate for standard CRC applications. Mold designs for specific CRC neck finishes (28 mm, 33 mm, 38 mm, 45 mm CRC standards) are available with dimensional validation reports on request.
Q7: Is batch logging and production traceability available?
Yes. The pharmaceutical-grade PLC configuration includes batch logging that records output count, reject count, cycle time data, and oven zone power data per production batch. This data supports the manufacturing batch record documentation required by pharmaceutical GMP quality systems. Data export via USB or Ethernet is available. Full electronic batch records with electronic signature (21 CFR Part 11 compliance) can be configured on request for regulated pharmaceutical facilities.
Q8: What is the production lead time from order to delivery?
Standard ES-series and AS-series machines are produced within 45–60 working days from deposit receipt. Pharmaceutical blow molds for confirmed 3D bottle designs are delivered in 30–40 working days — slightly longer than standard packaging molds due to the tighter dimensional tolerances and CRC neck-finish geometry. Preform injection molds take 40–55 working days. Factory acceptance testing with bottle samples and dimensional measurement reports is conducted before shipment.
Q9: What certifications do the machines carry?
All machines are CE-marked and carry multiple national utility model patents. ECM verification certificates for electrical components are available. Country-specific certifications (UL, EAC, INMETRO, etc.) can be supported subject to additional testing. Documentation confirming no-hand-contact no-hydraulic-fluid architecture is provided for pharmaceutical GMP qualification submissions. IQ/OQ (Installation Qualification / Operational Qualification) protocol documentation is available for pharmaceutical facility qualification requirements.
Q10: Can these machines integrate with downstream pharmaceutical filling lines?
Yes. All models include an inline bottle conveyor with standard interface dimensions compatible with downstream filling, stoppering, capping, induction sealing, and labelling equipment. For pharmaceutical filling lines requiring enclosed transfer between blow molder and filler (to maintain container cleanliness), enclosed conveyor tunnel options are available. Line-speed matching calculations and buffer conveyor sizing recommendations are provided at the project planning stage.

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blow molding machine production workshop pharmaceutical medicine bottle blow molder assembly quality control

10. Work with a Specialist Manufacturer

With over two decades of dedicated experience in blow molding machine design, manufacturing, and after-sales service, we supply automatic PET pharmaceutical and medicine bottle blow molding machines to pharmaceutical manufacturers, contract packaging organisations, nutraceutical producers, and healthcare packaging specialists across more than 20 countries. Our production facility operates dedicated CNC machining, precision pharmaceutical mold fabrication, machine assembly, and quality-control departments. Our engineers are available globally for installation, commissioning, IQ/OQ documentation support, and after-sales service.

Whether you are specifying your first pharmaceutical blow molder, adding a dedicated eye-drop bottle platform, scaling up nutraceutical supplement production capacity, or replacing an ageing European pharmaceutical packaging machine, our technical team will provide a no-obligation specification review and delivered-cost comparison within 48 hours of enquiry.

Ready to Specify Your Pharmaceutical Bottle Blow Molding Machine?

Send us your bottle drawing or sample, target daily output, neck finish and closure specification, and GMP documentation requirements — our engineering team will recommend the optimal automatic blow molding machine and issue a direct quotation.

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